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Compound Detail

CHEMBL4850702

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COc1ccc(S(=O)(=O)N2CCN(c3ccc(C)cc3)CC2)cc1S(=O)(=O)N1CCN(c2ccc(C)cc2)CC1

Basic Information

ChEMBL ID CHEMBL4850702
Phase Preclinical
Structure Type MOL
InChI Key IOGCNAFJEIQTDY-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

584.8
MW (Da)
3.33
ALogP
7
HBA
0
HBD
90.5
PSA (Ų)
0.42
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H36N4O5S2
MW 584.76
Aromatic Rings 3
Heavy Atoms 40
NP-Likeness -1.27

Activity Summary

IC50 1 meas. best 6.17

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Blood
CHEMBL613444
IC50 6.17 6.17 680.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Blood IC50 = 680.0 nM 6.17 Anti-platelet aggregation activity in rabbit venous blood assessed as inhibition... 34500186

Literature References

PubMed DOI Target Context # Activities
34500186 10.1016/j.bmc.2021.116390 Blood 4

Data from ChEMBL 36 via Core Engine