Assay Detail
Functional
CHEMBL4825385
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Anti-platelet aggregation activity in rabbit venous blood assessed as inhibition of arachidonic acid-induced aggregation pre-treated for 2 mins followed by ADP addition by Born turbidimetric method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Blood |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, in vitro cytotoxicity and biological evaluation of twenty novel 1,3-benzenedisulfonyl piperazines as antiplatelet agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.35 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4865125 | — | — | 1 | 6.58 |
| CHEMBL4848168 | — | — | 1 | 6.48 |
| CHEMBL1257015 | PICOTAMIDE | -1.0 | 1 | 6.47 |
| CHEMBL4857136 | — | — | 1 | 6.44 |
| CHEMBL4873253 | — | — | 1 | 6.37 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 6.37 |
| CHEMBL4859634 | — | — | 1 | 6.32 |
| CHEMBL4870486 | — | — | 1 | 6.19 |
| CHEMBL4850702 | — | — | 1 | 6.17 |
| CHEMBL4852106 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4865125 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4848168 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1257015 | PICOTAMIDE | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4857136 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4873253 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL25 | ASPIRIN | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4859634 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4870486 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4850702 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4852106 | — | IC50 | = | 710.0 | nM | 6.15 |