Compound Detail
CHEMBL1257015
PICOTAMIDE Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1257015 |
| Name | PICOTAMIDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KYWCWBXGRWWINE-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
3
Targets
7
Activities
1
Assay Types
0
PK Parameters
20
Publications
3
Known Names
1
Indications
2
Mechanisms
Molecular Properties
376.4
MW (Da)
2.35
ALogP
5
HBA
2
HBD
93.2
PSA (Ų)
0.66
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Thromboxane-A synthase inhibitor | INHIBITOR | Thromboxane-A synthase | ✓ | ✓ |
| Thromboxane A2 receptor inhibitor | INHIBITOR | Thromboxane A2 receptor | ✓ | ✓ |
Indications
Thrombosis
ATC Classification
B01AC03
picotamide
Level 1: BLOOD AND BLOOD FORMING ORGANS
Level 2: ANTITHROMBOTIC AGENTS
Activity Summary
IC50 7 meas. best 6.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Blood CHEMBL613444 | IC50 | 6.47 | 6.4 | 340.0 | 2 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 6.12 | 6.12 | 760.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 5.5 | 5.5 | 3162.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Blood | IC50 | = | 340.0 | nM | 6.47 | Anti-platelet aggregation activity in rabbit venous blood assessed as inhibition... | 34500186 |
| Blood | IC50 | = | 470.0 | nM | 6.33 | Anti-platelet aggregation activity in rabbit venous blood assessed as inhibition... | 34500186 |
| NON-PROTEIN TARGET | IC50 | = | 760.0 | nM | 6.12 | Antiplatelet activity against rat platelet rich plasma assessed as inhibition of... | 23010272 |
| Plasmodium falciparum | IC50 | = | 3162.28 | nM | 5.5 | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR g... | 19734910 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34500186 | 10.1016/j.bmc.2021.116390 | Blood | 5 |
| 37468498 | 10.1038/s41467-023-40064-9 | Nuclear receptor subfamily 1 group I member 2 | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Progesterone receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Gamma-aminobutyric acid receptor subunit alpha-1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Beta-1 adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2B | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Cannabinoid receptor 1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 1A | 2 |
| 21965623 | 10.1124/dmd.111.040758 | Bile salt export pump | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-2A adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2A | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Androgen receptor | 2 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
| 29432947 | 10.1016/j.ejmech.2018.01.097 | Platelet | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine