Compound Detail
CHEMBL485196
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Basic Information
| ChEMBL ID | CHEMBL485196 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CEEDKNHIBNHBQW-UHFFFAOYSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
382.4
MW (Da)
3.11
ALogP
5
HBA
3
HBD
112.7
PSA (Ų)
0.73
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.4
EC50 1 meas. best 7.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hydroxycarboxylic acid receptor 2 CHEMBL3785 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
| Hydroxycarboxylic acid receptor 2 CHEMBL3785 | EC50 | 7.72 | 7.72 | 19.0 | 1 |
| Cytochrome P450 2C9 CHEMBL3397 | IC50 | 4.96 | 4.96 | 11000.0 | 1 |
| Cytochrome P450 2C8 CHEMBL3721 | IC50 | 4.36 | 4.36 | 44000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hydroxycarboxylic acid receptor 2 | IC50 | = | 4.0 | nM | 8.4 | Displacement of [3H]niacin from human GPR109A expressed in CHO cells | 19309152 |
| Hydroxycarboxylic acid receptor 2 | EC50 | = | 19.0 | nM | 7.72 | Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS bin... | 19309152 |
| Cytochrome P450 2C9 | IC50 | = | 11000.0 | nM | 4.96 | Inhibition of CYP2C9 in human liver microsomes using diclofenac substrate | 19309152 |
| Cytochrome P450 2C8 | IC50 | = | 44000.0 | nM | 4.36 | Inhibition of CYP2C8 in human liver microsomes using montelukast substrate | 19309152 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19309152 | 10.1021/jm900151e | Hydroxycarboxylic acid receptor 2 | 3 |
| 19309152 | 10.1021/jm900151e | Adipocyte | 1 |
| 19309152 | 10.1021/jm900151e | Cytochrome P450 2C8 | 1 |
| 19309152 | 10.1021/jm900151e | Cytochrome P450 2C9 | 1 |
Data from ChEMBL 36 via Core Engine