Compound Detail
CHEMBL485242
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Basic Information
| ChEMBL ID | CHEMBL485242 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QILACADJNNDLKC-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
403.5
MW (Da)
4.48
ALogP
5
HBA
0
HBD
47.4
PSA (Ų)
0.64
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL264 | IC50 | 8.0 | 8.0 | 10.0 | 1 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 5.14 | 5.14 | 7300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | IC50 | = | 10.0 | nM | 8.0 | Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 ce... | 18841880 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 7300.0 | nM | 5.14 | Antagonist activity at human ERG in HEK293 cells assessed as inhibition of [35S]... | 18841880 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18841880 | 10.1021/jm800569w | Histamine H3 receptor | 1 |
| 18841880 | 10.1021/jm800569w | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine