Compound Detail
CHEMBL486145
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Basic Information
| ChEMBL ID | CHEMBL486145 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZUXGFKWBSMEYJC-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
266.3
MW (Da)
2.86
ALogP
2
HBA
1
HBD
46.5
PSA (Ų)
0.87
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Free fatty acid receptor 1 CHEMBL4422 | EC50 | 5.43 | 5.43 | 3715.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Free fatty acid receptor 1 | EC50 | = | 3715.35 | nM | 5.43 | Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluore... | 18947221 |
| Free fatty acid receptor 1 | EC50 | = | 3715.0 | nM | 5.43 | Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells... | 31279294 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18947221 | 10.1021/jm8010178 | Free fatty acid receptor 1 | 2 |
| 18947221 | 10.1021/jm8010178 | Free fatty acid receptor 2 | 1 |
| 18947221 | 10.1021/jm8010178 | Free fatty acid receptor 3 | 1 |
| 31279294 | 10.1016/j.ejmech.2019.06.087 | Free fatty acid receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine