Assay Detail
Functional
CHEMBL4354542
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel FFA1/GPR40 agonists: New breakthrough in an old scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 7.16 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4460582 | — | — | 1 | 8.32 |
| CHEMBL4575598 | — | — | 1 | 7.94 |
| CHEMBL1688473 | — | — | 1 | 7.85 |
| CHEMBL4593950 | — | — | 1 | 7.80 |
| CHEMBL4438440 | — | — | 1 | 7.71 |
| CHEMBL4537190 | — | — | 1 | 7.65 |
| CHEMBL4570807 | — | — | 1 | 7.62 |
| CHEMBL4534840 | — | — | 1 | 7.44 |
| CHEMBL4471403 | — | — | 1 | 7.44 |
| CHEMBL1829174 | FASIGLIFAM | 3.0 | 1 | 7.43 |
| CHEMBL4450552 | — | — | 1 | 7.41 |
| CHEMBL4442354 | — | — | 1 | 7.38 |
| CHEMBL4468987 | — | — | 1 | 7.38 |
| CHEMBL4550165 | — | — | 1 | 7.34 |
| CHEMBL4461611 | — | — | 1 | 7.29 |
| CHEMBL4574808 | — | — | 1 | 7.29 |
| CHEMBL4577954 | — | — | 1 | 7.23 |
| CHEMBL4537797 | — | — | 1 | 7.22 |
| CHEMBL3628756 | — | — | 1 | 7.16 |
| CHEMBL4561122 | — | — | 1 | 7.16 |
| CHEMBL4458669 | — | — | 1 | 7.06 |
| CHEMBL4516052 | — | — | 1 | 6.71 |
| CHEMBL4469534 | — | — | 1 | 6.65 |
| CHEMBL4464317 | — | — | 1 | 6.40 |
| CHEMBL4519415 | — | — | 1 | 6.27 |
| CHEMBL4469691 | — | — | 1 | 6.14 |
| CHEMBL206880 | — | — | 1 | 5.69 |
| CHEMBL486145 | — | — | 1 | 5.43 |
| CHEMBL4442156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4460582 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4575598 | — | EC50 | = | 11.6 | nM | 7.94 |
| CHEMBL1688473 | — | EC50 | = | 14.2 | nM | 7.85 |
| CHEMBL4593950 | — | EC50 | = | 15.7 | nM | 7.80 |
| CHEMBL4438440 | — | EC50 | = | 19.3 | nM | 7.71 |
| CHEMBL4537190 | — | EC50 | = | 22.5 | nM | 7.65 |
| CHEMBL4570807 | — | EC50 | = | 24.2 | nM | 7.62 |
| CHEMBL4534840 | — | EC50 | = | 36.1 | nM | 7.44 |
| CHEMBL4471403 | — | EC50 | = | 36.5 | nM | 7.44 |
| CHEMBL1829174 | FASIGLIFAM | EC50 | = | 37.1 | nM | 7.43 |
| CHEMBL4450552 | — | EC50 | = | 38.7 | nM | 7.41 |
| CHEMBL4442354 | — | EC50 | = | 41.9 | nM | 7.38 |
| CHEMBL4468987 | — | EC50 | = | 41.3 | nM | 7.38 |
| CHEMBL4550165 | — | EC50 | = | 45.6 | nM | 7.34 |
| CHEMBL4461611 | — | EC50 | = | 51.7 | nM | 7.29 |
| CHEMBL4574808 | — | EC50 | = | 51.6 | nM | 7.29 |
| CHEMBL4577954 | — | EC50 | = | 58.5 | nM | 7.23 |
| CHEMBL4537797 | — | EC50 | = | 59.8 | nM | 7.22 |
| CHEMBL3628756 | — | EC50 | = | 69.3 | nM | 7.16 |
| CHEMBL4561122 | — | EC50 | = | 69.6 | nM | 7.16 |
| CHEMBL4458669 | — | EC50 | = | 86.2 | nM | 7.06 |
| CHEMBL4516052 | — | EC50 | = | 196.7 | nM | 6.71 |
| CHEMBL4469534 | — | EC50 | = | 225.3 | nM | 6.65 |
| CHEMBL4464317 | — | EC50 | = | 397.5 | nM | 6.40 |
| CHEMBL4519415 | — | EC50 | = | 536.2 | nM | 6.27 |
| CHEMBL4469691 | — | EC50 | = | 728.6 | nM | 6.14 |
| CHEMBL206880 | — | EC50 | = | 2041.0 | nM | 5.69 |
| CHEMBL486145 | — | EC50 | = | 3715.0 | nM | 5.43 |
| CHEMBL4442156 | — | EC50 | > | 1000.0 | nM | - |