Compound Detail
CHEMBL4861544
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CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CCC(=O)NCCCNC(=O)NC(=N)NCCC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC1=O
Basic Information
| ChEMBL ID | CHEMBL4861544 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IAIZTRAAUSPLQL-JPRYDEJLSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
1107.3
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.87
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide Y receptor type 4 CHEMBL4877 | Ki | 6.87 | 6.86 | 134.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 4 | Ki | = | 134.9 | nM | 6.87 | Displacement of [3H]UR-KK200 from human neuropeptide Y Y4 receptor expressed in ... | 34748345 |
| Neuropeptide Y receptor type 4 | Ki | = | 140.0 | nM | 6.85 | Displacement of [3H]UR-KK200 from human neuropeptide Y Y4 receptor expressed in ... | 34748345 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34748345 | 10.1021/acs.jmedchem.1c01574 | Neuropeptide Y receptor type 4 | 10 |
| 34748345 | 10.1021/acs.jmedchem.1c01574 | Neuropeptide Y receptor type 1 | 2 |
| 34748345 | 10.1021/acs.jmedchem.1c01574 | Neuropeptide Y receptor type 2 | 2 |
| 34748345 | 10.1021/acs.jmedchem.1c01574 | Neuropeptide Y receptor type 5 | 2 |
Data from ChEMBL 36 via Core Engine