Compound Detail
CHEMBL4864450
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Basic Information
| ChEMBL ID | CHEMBL4864450 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KLBAFFQVHQFLEL-WKILWMFISA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
405.4
MW (Da)
4.35
ALogP
6
HBA
2
HBD
82.9
PSA (Ų)
0.74
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C theta type CHEMBL3920 | IC50 | 5.96 | 5.96 | 1100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C theta type | IC50 | = | 1100.0 | nM | 5.96 | Inhibition of PKA-theta (unknown origin) using Fam-labelled S6-derived peptide i... | 34355886 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34355886 | 10.1021/acs.jmedchem.1c00388 | Protein kinase C theta type | 1 |
| 34355886 | 10.1021/acs.jmedchem.1c00388 | Protein kinase C delta type | 1 |
Data from ChEMBL 36 via Core Engine