Compound Detail
CHEMBL4867007
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Basic Information
| ChEMBL ID | CHEMBL4867007 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YRRYGKYWFQIDQT-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
439.9
MW (Da)
3.60
ALogP
5
HBA
1
HBD
75.4
PSA (Ų)
0.66
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 7 CHEMBL2157850 | IC50 | 5.89 | 5.53 | 1300.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 7 | IC50 | = | 1300.0 | nM | 5.89 | Inhibition of human USP7 using Ub-AMC as substrate | 32092586 |
| Ubiquitin carboxyl-terminal hydrolase 7 | IC50 | = | 6788.0 | nM | 5.17 | Inhibition of recombinant USP7 catalytic domain (unknown origin) using UbA10 as ... | 33684824 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33684824 | 10.1016/j.ejmech.2021.113291 | Ubiquitin carboxyl-terminal hydrolase 7 | 1 |
| 32092586 | 10.1016/j.ejmech.2020.112107 | Ubiquitin carboxyl-terminal hydrolase 7 | 1 |
Data from ChEMBL 36 via Core Engine