Assay Detail
Binding
CHEMBL5234060
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Inhibition of human USP7 using Ub-AMC as substrate
44
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ubiquitin carboxyl-terminal hydrolase 7 (CHEMBL2157850) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.67 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4548694 | — | — | 2 | 7.05 |
| CHEMBL5285615 | — | — | 1 | 6.89 |
| CHEMBL5290122 | — | — | 1 | 6.62 |
| CHEMBL5291393 | — | — | 1 | 6.57 |
| CHEMBL5286779 | — | — | 1 | 6.46 |
| CHEMBL2398212 | — | — | 1 | 6.40 |
| CHEMBL5277160 | — | — | 1 | 6.38 |
| CHEMBL5272524 | — | — | 1 | 6.32 |
| CHEMBL5280940 | — | — | 1 | 6.25 |
| CHEMBL4867007 | — | — | 1 | 5.89 |
| CHEMBL5269711 | — | — | 1 | 5.65 |
| CHEMBL3407548 | — | — | 1 | 5.59 |
| CHEMBL4569978 | — | — | 1 | 5.46 |
| CHEMBL5281075 | — | — | 1 | 5.37 |
| CHEMBL4584162 | — | — | 1 | 5.14 |
| CHEMBL5281777 | — | — | 2 | 5.14 |
| CHEMBL4550273 | — | — | 1 | 4.99 |
| CHEMBL4867215 | — | — | 1 | 4.92 |
| CHEMBL4515695 | — | — | 1 | 4.90 |
| CHEMBL5276040 | — | — | 1 | 4.75 |
| CHEMBL5282532 | — | — | 1 | 4.66 |
| CHEMBL5285600 | — | — | 1 | 4.40 |
| CHEMBL5283229 | — | — | 1 | 4.18 |
| CHEMBL5291327 | — | — | 1 | - |
| CHEMBL5271202 | — | — | 1 | - |
| CHEMBL5282006 | — | — | 1 | - |
| CHEMBL5283065 | — | — | 1 | - |
| CHEMBL5268568 | — | — | 1 | - |
| CHEMBL5282900 | — | — | 1 | - |
| CHEMBL4442330 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4548694 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5285615 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4548694 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5290122 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5291393 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5286779 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2398212 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5277160 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5272524 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5280940 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4867007 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5269711 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL3407548 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL4569978 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5281075 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5281777 | — | IC50 | = | 7180.0 | nM | 5.14 |
| CHEMBL4584162 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4550273 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL5281777 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4867215 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4515695 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL5276040 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5282532 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL5285600 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL5283229 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL4438288 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4460617 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5270413 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4516637 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4583430 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5274053 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5272836 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4442330 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5276519 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5280738 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5277194 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5271202 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5282006 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5283065 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4580655 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5268568 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5282900 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5291327 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5287308 | — | IC50 | > | 100000.0 | nM | - |