Compound Detail
CHEMBL4867215
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Basic Information
| ChEMBL ID | CHEMBL4867215 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CITWIBXKKHFDFM-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
425.9
MW (Da)
3.04
ALogP
5
HBA
1
HBD
75.4
PSA (Ų)
0.68
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.71
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 7 CHEMBL2157850 | IC50 | 6.71 | 5.5133 | 193.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 7 | IC50 | = | 193.0 | nM | 6.71 | Inhibition of full length His-tagged human recombinant USP7 | 38262120 |
| Ubiquitin carboxyl-terminal hydrolase 7 | IC50 | = | 12000.0 | nM | 4.92 | Inhibition of human USP7 using Ub-AMC as substrate | 32092586 |
| Ubiquitin carboxyl-terminal hydrolase 7 | IC50 | = | 12300.0 | nM | 4.91 | Inhibition of recombinant USP7 catalytic domain (unknown origin) using UbA10 as ... | 33684824 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33684824 | 10.1016/j.ejmech.2021.113291 | MGC-803 | 2 |
| 33684824 | 10.1016/j.ejmech.2021.113291 | BGC-823 | 2 |
| 33684824 | 10.1016/j.ejmech.2021.113291 | Ubiquitin carboxyl-terminal hydrolase 7 | 1 |
| 32092586 | 10.1016/j.ejmech.2020.112107 | Ubiquitin carboxyl-terminal hydrolase 7 | 1 |
| 38262120 | 10.1016/j.ejmech.2024.116161 | Ubiquitin carboxyl-terminal hydrolase 7 | 1 |
Data from ChEMBL 36 via Core Engine