Compound Detail
CHEMBL5282532
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Basic Information
| ChEMBL ID | CHEMBL5282532 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TYBCVYRWTFEZDR-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
223.2
MW (Da)
1.27
ALogP
5
HBA
1
HBD
86.9
PSA (Ų)
0.62
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 8 CHEMBL2157854 | IC50 | 5.08 | 5.08 | 8400.0 | 1 |
| Ubiquitin carboxyl-terminal hydrolase 7 CHEMBL2157850 | IC50 | 4.66 | 4.66 | 21800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 8 | IC50 | = | 8400.0 | nM | 5.08 | Inhibition of human USP8 using Ub-AMC as substrate | 32092586 |
| Ubiquitin carboxyl-terminal hydrolase 7 | IC50 | = | 21800.0 | nM | 4.66 | Inhibition of human USP7 using Ub-AMC as substrate | 32092586 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32092586 | 10.1016/j.ejmech.2020.112107 | Ubiquitin carboxyl-terminal hydrolase 7 | 1 |
| 32092586 | 10.1016/j.ejmech.2020.112107 | Ubiquitin carboxyl-terminal hydrolase 8 | 1 |
Data from ChEMBL 36 via Core Engine