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Compound Detail

CHEMBL4870613

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C[C@](O)(Cn1cncc1Br)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1

Basic Information

ChEMBL ID CHEMBL4870613
Phase Preclinical
Structure Type MOL
InChI Key IHDLBAQVJIXGKH-AWEZNQCLSA-N
1
Targets
3
Activities
1
Assay Types
1
PK Parameters
2
Publications
0
Known Names

Molecular Properties

417.2
MW (Da)
2.93
ALogP
5
HBA
2
HBD
90.9
PSA (Ų)
0.80
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H12BrF3N4O2
MW 417.19
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -1.40

Activity Summary

IC50 3 meas. best 5.99

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Androgen receptor
CHEMBL1871
IC50 5.99 5.99 1019.0 3

Pharmacokinetic Data

Parameter Value Units Species
T1/2 0.4418 hr Mus musculus

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
34269581 10.1021/acs.jmedchem.1c00439 Androgen receptor 4
34269581 10.1021/acs.jmedchem.1c00439 ADMET 2

Data from ChEMBL 36 via Core Engine