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Compound Detail

CHEMBL4871850

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O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1

Basic Information

ChEMBL ID CHEMBL4871850
Phase Preclinical
Structure Type MOL
InChI Key ZEDZOJZPJMLGQC-UHFFFAOYSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

339.4
MW (Da)
2.79
ALogP
4
HBA
0
HBD
36.4
PSA (Ų)
0.86
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H22FN3O
MW 339.41
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -1.44

Activity Summary

Ki 5 meas. best 7.94

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 1A
CHEMBL214
Ki 7.94 7.94 11.4 1
5-hydroxytryptamine receptor 7
CHEMBL3155
Ki 7.92 7.92 11.9 1
D(4) dopamine receptor
CHEMBL219
Ki 7.38 7.38 41.4 1
5-hydroxytryptamine receptor 2A
CHEMBL224
Ki 7.12 7.12 75.9 1
D(3) dopamine receptor
CHEMBL234
Ki 5.83 5.83 1469.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
33582388 10.1016/j.ejmech.2021.113243 D(3) dopamine receptor 1
33582388 10.1016/j.ejmech.2021.113243 D(4) dopamine receptor 1
33582388 10.1016/j.ejmech.2021.113243 5-hydroxytryptamine receptor 1A 1
33582388 10.1016/j.ejmech.2021.113243 5-hydroxytryptamine receptor 2A 1
33582388 10.1016/j.ejmech.2021.113243 5-hydroxytryptamine receptor 7 1
33582388 10.1016/j.ejmech.2021.113243 D(2) dopamine receptor 1
33582388 10.1016/j.ejmech.2021.113243 5-hydroxytryptamine receptor 2C 1
33582388 10.1016/j.ejmech.2021.113243 Sodium-dependent serotonin transporter 1

Data from ChEMBL 36 via Core Engine