Compound Detail
CHEMBL487265
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Basic Information
| ChEMBL ID | CHEMBL487265 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IEKCOXKNCRBHNT-AZUAARDMSA-N |
1
Targets
2
Activities
1
Assay Types
3
PK Parameters
2
Publications
0
Known Names
Molecular Properties
340.5
MW (Da)
2.18
ALogP
3
HBA
1
HBD
43.8
PSA (Ų)
0.89
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL4124 | Ki | 8.22 | 8.21 | 6.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| F | 39.0 | % | Rattus norvegicus |
| T1/2 | 1.8 | hr | Rattus norvegicus |
| Tmax | 0.6 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Ki | = | 6.0 | nM | 8.22 | Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex m... | 18554904 |
| Histamine H3 receptor | Ki | = | 6.31 | nM | 8.2 | Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex m... | 18554904 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18554904 | 10.1016/j.bmcl.2008.05.086 | Rattus norvegicus | 3 |
| 18554904 | 10.1016/j.bmcl.2008.05.086 | Histamine H3 receptor | 2 |
Data from ChEMBL 36 via Core Engine