Compound Detail
CHEMBL4874296
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Basic Information
| ChEMBL ID | CHEMBL4874296 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UCEJVJFDKNVXDE-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
346.4
MW (Da)
3.91
ALogP
3
HBA
2
HBD
61.0
PSA (Ų)
0.75
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.91
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity nerve growth factor receptor CHEMBL2815 | IC50 | 5.91 | 5.91 | 1240.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity nerve growth factor receptor | IC50 | = | 1240.0 | nM | 5.91 | Inhibition of N-terminal GST-tagged human TRKA (436 to 790 residues) expressed i... | 34171657 |
| High affinity nerve growth factor receptor | IC50 | = | 1240.0 | nM | 5.91 | Inhibition of human intracellular domain of TRKA expressed in Sf9 cells incubate... | 37413881 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34171657 | 10.1016/j.ejmech.2021.113627 | High affinity nerve growth factor receptor | 1 |
| 37413881 | 10.1016/j.ejmech.2023.115618 | High affinity nerve growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine