Compound Detail
CHEMBL487435
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CC[C@@H](C)[C@H](NC(=O)c1cc(Cc2ccc(O)cc2)cc(NC(=O)[C@@H](N)C(C)C)c1)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL487435 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BIJUDPHLIRJQPE-YDFBLROQSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
455.6
MW (Da)
3.13
ALogP
5
HBA
5
HBD
141.8
PSA (Ų)
0.37
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 4.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Aminopeptidase N CHEMBL1907 | Ki | 4.16 | 4.16 | 69000.0 | 1 |
| Leucyl-cystinyl aminopeptidase CHEMBL2693 | Ki | 4.12 | 4.12 | 76000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Aminopeptidase N | Ki | = | 69000.0 | nM | 4.16 | Inhibition of human recombinant APN expressed in HEK293 cells | 18556208 |
| Leucyl-cystinyl aminopeptidase | Ki | = | 76000.0 | nM | 4.12 | Inhibition of human recombinant IRAP expressed in HEK293 cells | 18556208 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18556208 | 10.1016/j.bmc.2008.05.046 | Leucyl-cystinyl aminopeptidase | 2 |
| 18556208 | 10.1016/j.bmc.2008.05.046 | Aminopeptidase N | 1 |
Data from ChEMBL 36 via Core Engine