Compound Detail
CHEMBL4876693
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Basic Information
| ChEMBL ID | CHEMBL4876693 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PENYKQOAELQWRK-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
494.6
MW (Da)
5.60
ALogP
8
HBA
1
HBD
94.1
PSA (Ų)
0.33
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 7.44 | 7.44 | 36.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 36.23 | nM | 7.44 | Inhibition of PI3Kalpha (unknown origin) by ADP-Glo assay | 34795869 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34795869 | 10.1021/acsmedchemlett.1c00412 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 34795869 | 10.1021/acsmedchemlett.1c00412 | Serine/threonine-protein kinase mTOR | 1 |
| 34795869 | 10.1021/acsmedchemlett.1c00412 | Serine/threonine-protein kinase pim-1 | 1 |
Data from ChEMBL 36 via Core Engine