Compound Detail
CHEMBL4877869
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COc1ncc(N2CCOCC2)cc1S(=O)(=O)Nc1ccnc(-c2ccc(CN3CCN(C(C)(C)C)CC3)cc2)c1.O=CO
Basic Information
| ChEMBL ID | CHEMBL4877869 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HLASFDALSYSWPR-UHFFFAOYSA-N |
| Parent Compound | CHEMBL4165185 |
| Active Moiety | CHEMBL4165185 |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
580.8
MW (Da)
3.71
ALogP
9
HBA
1
HBD
100.1
PSA (Ų)
0.43
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| PI3-kinase p110-alpha/p85-alpha CHEMBL2111367 | IC50 | 5.8 | 5.8 | 1584.9 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | IC50 | 5.4 | 5.4 | 3981.1 | 1 |
| PI3K p110 beta/p85 alpha CHEMBL3038510 | IC50 | 5.2 | 5.2 | 6309.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| PI3-kinase p110-alpha/p85-alpha | IC50 | = | 1584.89 | nM | 5.8 | Inhibition of recombinant human N-terminal His6-tagged full length P110alpha/ful... | 34510892 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | IC50 | = | 3981.07 | nM | 5.4 | Inhibition of recombinant human N-terminal His6-tagged full length P120gamma exp... | 34510892 |
| PI3K p110 beta/p85 alpha | IC50 | = | 6309.57 | nM | 5.2 | Inhibition of recombinant human N-terminal His6-tagged full length P110beta/full... | 34510892 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34510892 | 10.1021/acs.jmedchem.1c01102 | PI3-kinase p110-alpha/p85-alpha | 1 |
| 34510892 | 10.1021/acs.jmedchem.1c01102 | PI3K p110 beta/p85 alpha | 1 |
| 34510892 | 10.1021/acs.jmedchem.1c01102 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
Data from ChEMBL 36 via Core Engine