Compound Detail
CHEMBL4877889
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4877889 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AFLQKPBFQDXTFP-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
344.4
MW (Da)
3.33
ALogP
4
HBA
2
HBD
67.4
PSA (Ų)
0.71
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.22
IC50 1 meas. best 5.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| STE20-like serine/threonine-protein kinase CHEMBL4202 | Ki | 8.22 | 8.22 | 6.0 | 1 |
| Serine/threonine-protein kinase 10 CHEMBL3981 | Ki | 7.33 | 7.33 | 47.0 | 1 |
| Serine/threonine-protein kinase 10 CHEMBL3981 | IC50 | 5.85 | 5.85 | 1420.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| STE20-like serine/threonine-protein kinase | Ki | = | 6.0 | nM | 8.22 | Binding affinity human SLK by binding displacement assay | 34463505 |
| Serine/threonine-protein kinase 10 | Ki | = | 47.0 | nM | 7.33 | Binding affinity human STK10 by binding displacement assay | 34463505 |
| Serine/threonine-protein kinase 10 | IC50 | = | 1420.0 | nM | 5.85 | Inhibition of STK10 (unknown origin) expressed in Sf9 cells assessed as transfer... | 34463505 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34463505 | 10.1021/acs.jmedchem.0c01579 | Serine/threonine-protein kinase 10 | 3 |
| 34463505 | 10.1021/acs.jmedchem.0c01579 | STE20-like serine/threonine-protein kinase | 2 |
| 34463505 | 10.1021/acs.jmedchem.0c01579 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine