Compound Detail
CHEMBL4878146
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4878146 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NWGBYGYHROJFLD-XBXGTLAGSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
389.4
MW (Da)
3.26
ALogP
5
HBA
3
HBD
103.8
PSA (Ų)
0.70
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C theta type CHEMBL3920 | IC50 | 6.82 | 6.82 | 150.0 | 1 |
| Protein kinase C delta type CHEMBL2996 | IC50 | 5.38 | 5.38 | 4200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C theta type | IC50 | = | 150.0 | nM | 6.82 | Inhibition of PKA-theta (unknown origin) using Fam-labelled S6-derived peptide i... | 34355886 |
| Protein kinase C delta type | IC50 | = | 4200.0 | nM | 5.38 | Inhibition of PKA-delta (unknown origin) using Fam-labelled S6-derived peptide i... | 34355886 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34355886 | 10.1021/acs.jmedchem.1c00388 | ADMET | 2 |
| 34355886 | 10.1021/acs.jmedchem.1c00388 | Protein kinase C theta type | 1 |
| 34355886 | 10.1021/acs.jmedchem.1c00388 | Protein kinase C delta type | 1 |
Data from ChEMBL 36 via Core Engine