Compound Detail
CHEMBL488337
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Basic Information
| ChEMBL ID | CHEMBL488337 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CVLQHWXSSKFZAF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
329.4
MW (Da)
3.05
ALogP
4
HBA
2
HBD
50.7
PSA (Ų)
0.74
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Extracellular calcium-sensing receptor CHEMBL1878 | IC50 | 5.64 | 5.64 | 2300.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.64 | 5.64 | 2300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 2300.0 | nM | 5.64 | Antagonist activity at human calcium receptor 1 expressed in HEK293 4.0-7 cells ... | 19492813 |
| Extracellular calcium-sensing receptor | IC50 | = | 2300.0 | nM | 5.64 | Binding affinity to human parathyroid calcium receptor 1 expressed in HEK293 4.0... | 19492813 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19492813 | 10.1021/jm900364m | Unchecked | 1 |
| 19492813 | 10.1021/jm900364m | Extracellular calcium-sensing receptor | 1 |
Data from ChEMBL 36 via Core Engine