Assay Detail
Functional
CHEMBL939871
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Antagonist activity at human calcium receptor 1 expressed in HEK293 4.0-7 cells assessed as inhibition of extracellular calcium-induced increase in intracellular calcium level by FLIPR assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.07 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523475 | — | — | 1 | 7.42 |
| CHEMBL487507 | — | — | 1 | 7.42 |
| CHEMBL2112075 | — | — | 1 | 7.37 |
| CHEMBL491251 | — | — | 1 | 7.35 |
| CHEMBL504479 | — | — | 1 | 7.35 |
| CHEMBL487508 | — | — | 1 | 6.47 |
| CHEMBL488736 | — | — | 1 | 6.35 |
| CHEMBL521907 | — | — | 1 | 6.33 |
| CHEMBL488997 | — | — | 1 | 6.31 |
| CHEMBL487511 | — | — | 1 | 5.85 |
| CHEMBL482874 | — | — | 1 | 5.66 |
| CHEMBL488337 | — | — | 1 | 5.64 |
| CHEMBL1162997 | — | — | 1 | 5.64 |
| CHEMBL520396 | — | — | 1 | 5.60 |
| CHEMBL482873 | — | — | 1 | 5.19 |
| CHEMBL486278 | — | — | 1 | 4.96 |
| CHEMBL483080 | — | — | 1 | 4.89 |
| CHEMBL4106263 | — | — | 1 | 4.81 |
| CHEMBL482462 | — | — | 1 | 4.80 |
| CHEMBL482875 | — | — | 1 | - |
| CHEMBL519645 | — | — | 1 | - |
| CHEMBL482876 | — | — | 1 | - |
| CHEMBL483079 | — | — | 1 | - |
| CHEMBL488737 | — | — | 1 | - |
| CHEMBL488738 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523475 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL487507 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2112075 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL491251 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL504479 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL487508 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL488736 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL521907 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL488997 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL487511 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL482874 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL488337 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1162997 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL520396 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL482873 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL486278 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL483080 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4106263 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL482462 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL482875 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL519645 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL482876 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL483079 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL488737 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL488738 | — | IC50 | > | 3000.0 | nM | - |