Compound Detail
CHEMBL488627
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Basic Information
| ChEMBL ID | CHEMBL488627 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RQSCVKBJVYRXTG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
390.4
MW (Da)
3.12
ALogP
4
HBA
4
HBD
112.7
PSA (Ų)
0.46
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 4.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Leucyl-cystinyl aminopeptidase CHEMBL2693 | Ki | 4.46 | 4.46 | 35000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Leucyl-cystinyl aminopeptidase | Ki | = | 35000.0 | nM | 4.46 | Inhibition of human recombinant IRAP expressed in HEK293 cells | 18556208 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18556208 | 10.1016/j.bmc.2008.05.046 | Leucyl-cystinyl aminopeptidase | 2 |
| 18556208 | 10.1016/j.bmc.2008.05.046 | Aminopeptidase N | 1 |
Data from ChEMBL 36 via Core Engine