Compound Detail
CHEMBL490561
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL490561 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QAVVXTWZLRCUOV-ZSEKCTLFSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
10
Publications
0
Known Names
Molecular Properties
375.4
MW (Da)
3.31
ALogP
5
HBA
1
HBD
74.0
PSA (Ų)
0.71
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide Y receptor type 5 CHEMBL4561 | Ki | 9.0 | 9.0 | 1.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 13.0 | mL.min-1.kg-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 5 | Ki | = | 1.0 | nM | 9.0 | Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expres... | 19459652 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19459652 | 10.1021/jm900110t | ADMET | 2 |
| 19616955 | 10.1016/j.bmc.2009.05.069 | Rattus norvegicus | 2 |
| 19459652 | 10.1021/jm900110t | Neuropeptide Y receptor type 5 | 1 |
| 19459652 | 10.1021/jm900110t | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 19459652 | 10.1021/jm900110t | No relevant target | 1 |
| 19459652 | 10.1021/jm900110t | Hepatocyte | 1 |
| 19459652 | 10.1021/jm900110t | Rattus norvegicus | 1 |
| 19459652 | 10.1021/jm900110t | Brain | 1 |
| 19459652 | 10.1021/jm900110t | Cerebrospinal fluid | 1 |
| 19616955 | 10.1016/j.bmc.2009.05.069 | Plasma | 1 |
Data from ChEMBL 36 via Core Engine