Compound Detail
CHEMBL490903
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL490903 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WPYUPZIYBIVRNB-JFZHLQQUSA-N |
| Parent Compound | CHEMBL1187117 |
| Active Moiety | CHEMBL1187117 |
2
Targets
2
Activities
2
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
384.8
MW (Da)
4.09
ALogP
4
HBA
1
HBD
50.2
PSA (Ų)
0.69
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.11
Ki 1 meas. best 8.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide Y receptor type 5 CHEMBL4561 | Ki | 8.74 | 8.74 | 1.8 | 1 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 5.11 | 5.11 | 7800.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 58.0 | mL.min-1.kg-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 5 | Ki | = | 1.8 | nM | 8.74 | Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expres... | 19459652 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 7800.0 | nM | 5.11 | Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4... | 19459652 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19459652 | 10.1021/jm900110t | Neuropeptide Y receptor type 5 | 1 |
| 19459652 | 10.1021/jm900110t | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 19459652 | 10.1021/jm900110t | No relevant target | 1 |
| 19459652 | 10.1021/jm900110t | Hepatocyte | 1 |
Data from ChEMBL 36 via Core Engine