Compound Detail
CHEMBL491981
7-HYDROXY ISOFLAVONE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL491981 |
| Name | 7-HYDROXY ISOFLAVONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WMKOZARWBMFKAS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
238.2
MW (Da)
3.17
ALogP
3
HBA
1
HBD
50.4
PSA (Ų)
0.71
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei brucei CHEMBL612851 | IC50 | 4.03 | 4.03 | 94200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei brucei | IC50 | = | 94200.0 | nM | 4.03 | Antitrypanosomal activity against Trypanosoma brucei brucei MITat 1.2 variant 22... | 16441066 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16441066 | 10.1021/np0502600 | Leishmania donovani | 1 |
| 16441066 | 10.1021/np0502600 | Trypanosoma brucei brucei | 1 |
| 16441066 | 10.1021/np0502600 | Vero | 1 |
| 21073191 | 10.1021/jm101206p | BDNF/NT-3 growth factors receptor | 1 |
| - | 10.1007/s00044-010-9415-1 | Plasma | 1 |
Data from ChEMBL 36 via Core Engine