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Compound Detail

CHEMBL492466

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CCn1c2ccccc2c2ccc(/C=N/n3cnnc3)cc21

Basic Information

ChEMBL ID CHEMBL492466
Phase Preclinical
Structure Type MOL
InChI Key ZYBOJMOHELISIV-KEBDBYFISA-N
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

289.3
MW (Da)
3.29
ALogP
5
HBA
0
HBD
48.0
PSA (Ų)
0.54
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H15N5
MW 289.34
Aromatic Rings 4
Heavy Atoms 22
NP-Likeness -1.31

Activity Summary

EC50 2 meas. best 4.3
IC50 2 meas.

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vaccinia virus
CHEMBL613493
EC50 4.3 4.3 50000.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18808105 10.1021/jm800366g Vaccinia virus 4
18808105 10.1021/jm800366g ADMET 3
18808105 10.1021/jm800366g Unchecked 1

Data from ChEMBL 36 via Core Engine