Compound Detail
CHEMBL492581
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Basic Information
| ChEMBL ID | CHEMBL492581 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BLWKVHOHRHEESG-MDZDMXLPSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
337.4
MW (Da)
2.99
ALogP
4
HBA
1
HBD
56.7
PSA (Ų)
0.87
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-2 CHEMBL4523 | IC50 | 7.34 | 7.32 | 46.0 | 2 |
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 7.3 | 7.3 | 50.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-2 | IC50 | = | 46.0 | nM | 7.34 | Inhibition of Pim2 in presence of 1 uM ATP | 19256503 |
| Serine/threonine-protein kinase pim-2 | IC50 | = | 50.0 | nM | 7.3 | Inhibition of Pim2 | 19256503 |
| Serine/threonine-protein kinase pim-1 | IC50 | = | 50.0 | nM | 7.3 | Inhibition of Pim1 in presence of 1 uM ATP | 19256503 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19256503 | 10.1021/jm801242y | Serine/threonine-protein kinase pim-2 | 2 |
| 19256503 | 10.1021/jm801242y | Serine/threonine-protein kinase pim-1 | 1 |
Data from ChEMBL 36 via Core Engine