Compound Detail
CHEMBL493296
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Basic Information
| ChEMBL ID | CHEMBL493296 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UXVQKIONVNQABP-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
337.4
MW (Da)
3.07
ALogP
6
HBA
1
HBD
66.9
PSA (Ų)
0.61
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.61
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 5.61 | 5.61 | 2450.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 2450.0 | nM | 5.61 | Inhibition of human recombinant PI3K p110alpha expressed in Sf9 cells coexpressi... | 18754654 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18754654 | 10.1021/jm800295d | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 18754654 | 10.1021/jm800295d | NON-PROTEIN TARGET | 1 |
| 18754654 | 10.1021/jm800295d | A2780 | 1 |
Data from ChEMBL 36 via Core Engine