Compound Detail
CHEMBL494667
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Basic Information
| ChEMBL ID | CHEMBL494667 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MCSLSGYTPAVGEY-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
259.3
MW (Da)
0.20
ALogP
6
HBA
2
HBD
87.0
PSA (Ų)
0.80
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.79
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H4 receptor CHEMBL3759 | EC50 | 7.79 | 7.79 | 16.2 | 1 |
| Histamine H4 receptor CHEMBL4468 | EC50 | 6.41 | 6.41 | 389.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H4 receptor | EC50 | = | 16.22 | nM | 7.79 | Agonist activity at human histamine H4 receptor expressed in HEK293 cells coexpr... | 18811133 |
| Histamine H4 receptor | EC50 | = | 389.05 | nM | 6.41 | Agonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpres... | 18811133 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18811133 | 10.1021/jm8005959 | Histamine H4 receptor | 4 |
Data from ChEMBL 36 via Core Engine