Compound Detail
CHEMBL496588
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL496588 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GIYYVKMTMUUEFI-XNTDXEJSSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
312.8
MW (Da)
3.43
ALogP
2
HBA
1
HBD
49.4
PSA (Ų)
0.70
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| PC-3 CHEMBL390 | IC50 | 4.17 | 4.17 | 67000.0 | 1 |
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 4.16 | 4.16 | 69000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| PC-3 | IC50 | = | 67000.0 | nM | 4.17 | Antiproliferative activity against human PC3 cells after 48 hrs by MTS assay | 19072652 |
| Serine/threonine-protein kinase pim-1 | IC50 | = | 69000.0 | nM | 4.16 | Inhibition of human recombinant Pim1 by ATP depletion assay | 19072652 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19072652 | 10.1021/jm800937p | Serine/threonine-protein kinase pim-1 | 1 |
| 19072652 | 10.1021/jm800937p | Serine/threonine-protein kinase pim-2 | 1 |
| 19072652 | 10.1021/jm800937p | PC-3 | 1 |
Data from ChEMBL 36 via Core Engine