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Assay Detail

CHEMBL957367

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human PC3 cells after 48 hrs by MTS assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PC-3
Confidence 1 — Organism
Curated By Autocuration

Target

PC-3 (CHEMBL390)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
Xia Z, Knaak C, Ma J, Beharry ZM, McInnes C, Wang W, Kraft AS, Smith CD.
J Med Chem (2009) 52 : 74 -86
PubMed 19072652 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 4.34 5.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL496784 1 5.50
CHEMBL496783 1 5.19
CHEMBL85496 1 4.96
CHEMBL183906 1 4.77
CHEMBL496971 1 4.75
CHEMBL495827 1 4.55
CHEMBL447567 1 4.42
CHEMBL84558 1 4.32
CHEMBL454557 1 4.32
CHEMBL496995 1 4.31
CHEMBL496972 1 4.24
CHEMBL496587 1 4.24
CHEMBL495398 1 4.20
CHEMBL86257 1 4.19
CHEMBL493742 1 4.19
CHEMBL493847 1 4.18
CHEMBL496588 1 4.17
CHEMBL497607 1 4.17
CHEMBL522916 1 4.17
CHEMBL496782 1 4.14
CHEMBL498203 1 4.13
CHEMBL496973 1 4.10
CHEMBL447741 1 4.10
CHEMBL448443 1 4.08
CHEMBL496996 1 4.07
CHEMBL506711 1 4.06
CHEMBL496786 1 4.03
CHEMBL498406 1 4.01
CHEMBL496994 1 -
CHEMBL526284 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL496784 IC50 = 3200.0 nM 5.50
CHEMBL496783 IC50 = 6400.0 nM 5.19
CHEMBL85496 IC50 = 11000.0 nM 4.96
CHEMBL183906 IC50 = 17000.0 nM 4.77
CHEMBL496971 IC50 = 18000.0 nM 4.75
CHEMBL495827 IC50 = 28000.0 nM 4.55
CHEMBL447567 IC50 = 38000.0 nM 4.42
CHEMBL84558 IC50 = 48000.0 nM 4.32
CHEMBL454557 IC50 = 48000.0 nM 4.32
CHEMBL496995 IC50 = 49000.0 nM 4.31
CHEMBL496972 IC50 = 57000.0 nM 4.24
CHEMBL496587 IC50 = 58000.0 nM 4.24
CHEMBL495398 IC50 = 63000.0 nM 4.20
CHEMBL86257 IC50 = 65000.0 nM 4.19
CHEMBL493742 IC50 = 65000.0 nM 4.19
CHEMBL493847 IC50 = 66000.0 nM 4.18
CHEMBL496588 IC50 = 67000.0 nM 4.17
CHEMBL522916 IC50 = 68000.0 nM 4.17
CHEMBL497607 IC50 = 68000.0 nM 4.17
CHEMBL496782 IC50 = 73000.0 nM 4.14
CHEMBL498203 IC50 = 74000.0 nM 4.13
CHEMBL496973 IC50 = 80000.0 nM 4.10
CHEMBL447741 IC50 = 80000.0 nM 4.10
CHEMBL448443 IC50 = 83000.0 nM 4.08
CHEMBL496996 IC50 = 85000.0 nM 4.07
CHEMBL506711 IC50 = 88000.0 nM 4.06
CHEMBL496786 IC50 = 93000.0 nM 4.03
CHEMBL498406 IC50 = 97000.0 nM 4.01
CHEMBL496994 IC50 > 100000.0 nM -
CHEMBL526284 IC50 > 100000.0 nM -
CHEMBL497606 IC50 > 100000.0 nM -
CHEMBL447571 IC50 > 100000.0 nM -