Compound Detail
CHEMBL86257
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Basic Information
| ChEMBL ID | CHEMBL86257 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GIRVZKMQGSXZKT-YFHOEESVSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
249.3
MW (Da)
2.41
ALogP
4
HBA
1
HBD
55.4
PSA (Ų)
0.84
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 6.77 | 6.77 | 170.0 | 1 |
| PC-12 CHEMBL612556 | IC50 | 4.57 | 4.57 | 27000.0 | 1 |
| Serine/threonine-protein kinase pim-2 CHEMBL4523 | IC50 | 4.37 | 4.37 | 43000.0 | 1 |
| PC-3 CHEMBL390 | IC50 | 4.19 | 4.19 | 65000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | IC50 | = | 170.0 | nM | 6.77 | Inhibition of human recombinant Pim1 by ATP depletion assay | 19072652 |
| PC-12 | IC50 | = | 27000.0 | nM | 4.57 | Concentration required for 50% inhibition of cell proliferation in PC12 cells us... | 15109648 |
| Serine/threonine-protein kinase pim-2 | IC50 | = | 43000.0 | nM | 4.37 | Inhibition of human recombinant Pim2 by ATP depletion assay | 19072652 |
| PC-3 | IC50 | = | 65000.0 | nM | 4.19 | Antiproliferative activity against human PC3 cells after 48 hrs by MTS assay | 19072652 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15109648 | 10.1016/j.bmcl.2004.02.087 | PC-12 | 3 |
| 19072652 | 10.1021/jm800937p | Mus musculus | 3 |
| 15109648 | 10.1016/j.bmcl.2004.02.087 | No relevant target | 1 |
| 19072652 | 10.1021/jm800937p | Serine/threonine-protein kinase pim-1 | 1 |
| 19072652 | 10.1021/jm800937p | Serine/threonine-protein kinase pim-2 | 1 |
| 19072652 | 10.1021/jm800937p | PC-3 | 1 |
Data from ChEMBL 36 via Core Engine