Assay Detail
Binding
CHEMBL957366
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant Pim2 by ATP depletion assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-2 (CHEMBL4523) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.29 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84558 | — | — | 1 | 7.70 |
| CHEMBL495398 | — | — | 1 | 7.40 |
| CHEMBL496782 | — | — | 1 | 7.40 |
| CHEMBL447567 | — | — | 1 | 7.10 |
| CHEMBL496996 | — | — | 1 | 7.05 |
| CHEMBL498406 | — | — | 1 | 7.00 |
| CHEMBL496587 | — | — | 1 | 7.00 |
| CHEMBL493847 | — | — | 1 | 7.00 |
| CHEMBL183906 | — | — | 1 | 7.00 |
| CHEMBL496995 | — | — | 1 | 6.70 |
| CHEMBL85496 | — | — | 1 | 6.52 |
| CHEMBL493742 | — | — | 1 | 6.52 |
| CHEMBL448443 | — | — | 1 | 6.40 |
| CHEMBL454557 | — | — | 1 | 6.30 |
| CHEMBL496783 | — | — | 1 | 6.05 |
| CHEMBL497607 | — | — | 1 | 5.82 |
| CHEMBL496784 | — | — | 1 | 5.66 |
| CHEMBL496786 | — | — | 1 | 5.64 |
| CHEMBL447571 | — | — | 1 | 5.36 |
| CHEMBL447741 | — | — | 1 | 4.38 |
| CHEMBL86257 | — | — | 1 | 4.37 |
| CHEMBL496971 | — | — | 1 | 4.00 |
| CHEMBL496973 | — | — | 1 | - |
| CHEMBL496972 | — | — | 1 | - |
| CHEMBL522916 | — | — | 1 | - |
| CHEMBL526284 | — | — | 1 | - |
| CHEMBL498203 | — | — | 1 | - |
| CHEMBL496588 | — | — | 1 | - |
| CHEMBL506711 | — | — | 1 | - |
| CHEMBL495827 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84558 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL495398 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL496782 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL447567 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL496996 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL498406 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL496587 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL493847 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL183906 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL496995 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL85496 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL493742 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL448443 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL454557 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL496783 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL497607 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL496784 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL496786 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL447571 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL447741 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL86257 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL496971 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL496973 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL496972 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL522916 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL526284 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL498203 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL496588 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL506711 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL495827 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL497606 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL496994 | — | IC50 | > | 100000.0 | nM | - |