Compound Detail
CHEMBL447571
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Basic Information
| ChEMBL ID | CHEMBL447571 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VUXDSWRSGDQYRJ-TWGQIWQCSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
219.3
MW (Da)
2.52
ALogP
2
HBA
1
HBD
49.7
PSA (Ų)
0.74
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
| Serine/threonine-protein kinase pim-2 CHEMBL4523 | IC50 | 5.36 | 5.36 | 4400.0 | 1 |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] CHEMBL1293255 | IC50 | 5.24 | 5.24 | 5820.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | IC50 | = | 60.0 | nM | 7.22 | Inhibition of human recombinant Pim1 by ATP depletion assay | 19072652 |
| Serine/threonine-protein kinase pim-2 | IC50 | = | 4400.0 | nM | 5.36 | Inhibition of human recombinant Pim2 by ATP depletion assay | 19072652 |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | IC50 | = | 5820.4 | nM | 5.24 | Inhibition Assay: Experimental was performed by measuring the formation of NADH ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22077389 | 10.1021/jm201243p | Unchecked | 3 |
| 19072652 | 10.1021/jm800937p | Serine/threonine-protein kinase pim-1 | 1 |
| 19072652 | 10.1021/jm800937p | Serine/threonine-protein kinase pim-2 | 1 |
| 19072652 | 10.1021/jm800937p | PC-3 | 1 |
| 22077389 | 10.1021/jm201243p | Prothrombin | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine