Compound Detail
CHEMBL497607
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Basic Information
| ChEMBL ID | CHEMBL497607 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MZSVGOACCCDXKW-UITAMQMPSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
333.3
MW (Da)
3.01
ALogP
5
HBA
1
HBD
64.6
PSA (Ų)
0.68
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 6.34 | 6.34 | 460.0 | 1 |
| Serine/threonine-protein kinase pim-2 CHEMBL4523 | IC50 | 5.82 | 5.82 | 1500.0 | 1 |
| PC-3 CHEMBL390 | IC50 | 4.17 | 4.17 | 68000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | IC50 | = | 460.0 | nM | 6.34 | Inhibition of human recombinant Pim1 by ATP depletion assay | 19072652 |
| Serine/threonine-protein kinase pim-2 | IC50 | = | 1500.0 | nM | 5.82 | Inhibition of human recombinant Pim2 by ATP depletion assay | 19072652 |
| PC-3 | IC50 | = | 68000.0 | nM | 4.17 | Antiproliferative activity against human PC3 cells after 48 hrs by MTS assay | 19072652 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19072652 | 10.1021/jm800937p | Serine/threonine-protein kinase pim-1 | 1 |
| 19072652 | 10.1021/jm800937p | Serine/threonine-protein kinase pim-2 | 1 |
| 19072652 | 10.1021/jm800937p | PC-3 | 1 |
Data from ChEMBL 36 via Core Engine