Compound Detail
CHEMBL501991
PERLOLYRIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL501991 |
| Name | PERLOLYRIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KFUCYPGCMLPUMT-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
13
Publications
0
Known Names
Molecular Properties
264.3
MW (Da)
3.47
ALogP
3
HBA
2
HBD
62.0
PSA (Ų)
0.58
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAW264.7 CHEMBL612557 | IC50 | 5.06 | 5.06 | 8700.0 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | IC50 | 5.03 | 5.03 | 9300.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAW264.7 | IC50 | = | 8700.0 | nM | 5.06 | Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-i... | 28499733 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 9300.0 | nM | 5.03 | Inhibition of PDE5 (unknown origin) | 29505934 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 9300.0 | nM | 5.03 | Inhibition of PDE5 (unknown origin) | 30245400 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21848266 | 10.1021/np100902f | NON-PROTEIN TARGET | 5 |
| 18715034 | 10.1021/np800248s | Staphylococcus aureus | 1 |
| 18715034 | 10.1021/np800248s | Bacillus subtilis | 1 |
| 18715034 | 10.1021/np800248s | Streptomyces viridochromogenes | 1 |
| 18715034 | 10.1021/np800248s | Escherichia coli | 1 |
| 18715034 | 10.1021/np800248s | Candida albicans | 1 |
| 18715034 | 10.1021/np800248s | Rhizomucor miehei | 1 |
| 18715034 | 10.1021/np800248s | Chlorella vulgaris | 1 |
| 18715034 | 10.1021/np800248s | Chlorella sorokiniana | 1 |
| 18715034 | 10.1021/np800248s | Desmodesmus subspicatus | 1 |
| 28499733 | 10.1016/j.bmcl.2017.04.072 | RAW264.7 | 1 |
| 29505934 | 10.1016/j.ejmech.2018.02.039 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
| 30245400 | 10.1016/j.ejmech.2018.09.028 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
Data from ChEMBL 36 via Core Engine