Compound Detail
CHEMBL503987
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Basic Information
| ChEMBL ID | CHEMBL503987 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XONPZWREUKIQIP-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
351.4
MW (Da)
2.07
ALogP
6
HBA
1
HBD
65.3
PSA (Ų)
0.61
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.07
Ki 1 meas. best 8.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 3A CHEMBL2411 | Ki | 8.47 | 8.47 | 3.4 | 1 |
| 5-hydroxytryptamine receptor 3A CHEMBL3666 | IC50 | 5.07 | 5.07 | 8511.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 3A | Ki | = | 3.4 | nM | 8.47 | Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenate | 19425598 |
| 5-hydroxytryptamine receptor 3A | IC50 | = | 8511.38 | nM | 5.07 | Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right a... | 19425598 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19425598 | 10.1021/jm900018b | 5-hydroxytryptamine receptor 3A | 5 |
Data from ChEMBL 36 via Core Engine