Compound Detail
CHEMBL506409
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL506409 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ALAIWCRFCPSHKS-UHFFFAOYSA-N |
1
Targets
5
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
191.6
MW (Da)
-0.14
ALogP
5
HBA
3
HBD
101.4
PSA (Ų)
0.56
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas.
Ki 1 meas. best 5.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | Ki | 5.54 | 5.54 | 2900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | Ki | = | 2900.0 | nM | 5.54 | Displacement of [3H]CGP39653 from NMDA receptor in rat cortical synaptosome | 18578474 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18578474 | 10.1021/jm800025e | Unchecked | 2 |
| 18578474 | 10.1021/jm800025e | Glutamate NMDA receptor; Grin1/Grin2a | 2 |
| 18578474 | 10.1021/jm800025e | Glutamate NMDA receptor; Grin1/Grin2b | 2 |
| 18578474 | 10.1021/jm800025e | Glutamate NMDA receptor; Grin1/Grin2c | 2 |
| 18578474 | 10.1021/jm800025e | Ionotropic glutamate receptor NMDA 1/2D | 2 |
| 18578474 | 10.1021/jm800025e | Glutamate NMDA receptor | 1 |
Data from ChEMBL 36 via Core Engine