Compound Detail
CHEMBL507605
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Basic Information
| ChEMBL ID | CHEMBL507605 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YYIPDVZMBORVLM-SFHVURJKSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
409.4
MW (Da)
2.59
ALogP
6
HBA
1
HBD
89.3
PSA (Ų)
0.68
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.89 | 6.785 | 130.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 130.0 | nM | 6.89 | Inhibition of 50S ribosomal subunit purified from Staphylococcus aureus ATCC 292... | 18663023 |
| Unchecked | IC50 | = | 210.0 | nM | 6.68 | Inhibition of 50S ribosomal subunit purified from linezolid-,erythromycin-resist... | 18663023 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18947996 | 10.1016/j.bmcl.2008.10.011 | Haemophilus influenzae | 4 |
| 18947996 | 10.1016/j.bmcl.2008.10.011 | Enterococcus faecalis | 3 |
| 18947996 | 10.1016/j.bmcl.2008.10.011 | Streptococcus pneumoniae | 3 |
| 18663023 | 10.1128/aac.01193-07 | Unchecked | 3 |
| 18663023 | 10.1128/aac.01193-07 | Staphylococcus aureus | 2 |
| 18663023 | 10.1128/aac.01193-07 | Enterococcus faecalis | 2 |
| 18947996 | 10.1016/j.bmcl.2008.10.011 | Staphylococcus aureus | 1 |
| 18947996 | 10.1016/j.bmcl.2008.10.011 | Streptococcus pyogenes | 1 |
| 18663023 | 10.1128/aac.01193-07 | Enterococcus faecium | 1 |
Data from ChEMBL 36 via Core Engine