Assay Detail
Binding
CHEMBL1282285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 50S ribosomal subunit purified from linezolid-,erythromycin-resistant Staphylococcus aureus A7820 with G2576U mutation in 23s rRNA assessed as inhibition of translation using in vitro transcribed mRNA encoding firefly luciferase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.38 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520063 | — | — | 1 | 7.52 |
| CHEMBL455461 | RADEZOLID | 2.0 | 1 | 7.52 |
| CHEMBL461534 | — | — | 1 | 7.22 |
| CHEMBL455466 | — | — | 1 | 7.22 |
| CHEMBL1276662 | — | — | 1 | 7.10 |
| CHEMBL507605 | — | — | 1 | 6.68 |
| CHEMBL126 | LINEZOLID | 4.0 | 1 | 5.08 |
| CHEMBL1241590 | FLORFENICOL | 2.0 | 1 | 4.79 |
| CHEMBL130 | CHLORAMPHENICOL | 4.0 | 1 | 4.27 |
| CHEMBL1275617 | — | — | 1 | - |
| CHEMBL1276632 | — | — | 1 | - |
| CHEMBL2303630 | SPARSOMYCIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520063 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL455461 | RADEZOLID | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL461534 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL455466 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1276662 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL507605 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL126 | LINEZOLID | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1241590 | FLORFENICOL | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL130 | CHLORAMPHENICOL | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL1275617 | — | IC50 | <= | 20.0 | nM | - |
| CHEMBL1276632 | — | IC50 | <= | 20.0 | nM | - |
| CHEMBL2303630 | SPARSOMYCIN | IC50 | <= | 20.0 | nM | - |