Compound Detail
CHEMBL1276662
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Basic Information
| ChEMBL ID | CHEMBL1276662 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PZRNNZUOTNIHDY-INIZCTEOSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
399.4
MW (Da)
1.94
ALogP
4
HBA
4
HBD
120.5
PSA (Ų)
0.44
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.1 | 7.1 | 80.0 | 1 |
| Bacterial 70S ribosome CHEMBL2363135 | IC50 | 5.06 | 4.68 | 8700.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 80.0 | nM | 7.1 | Inhibition of 50S ribosomal subunit purified from linezolid-,erythromycin-resist... | 18663023 |
| Bacterial 70S ribosome | IC50 | = | 8700.0 | nM | 5.06 | Displacement of [3H]puromycin from 70S ribosomal complex in Staphylococcus aureu... | 18663023 |
| Bacterial 70S ribosome | IC50 | = | 50000.0 | nM | 4.3 | Displacement of [3H]chloramphenicol from 70S ribosomal complex in Staphylococcus... | 18663023 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18663023 | 10.1128/aac.01193-07 | Unchecked | 3 |
| 18663023 | 10.1128/aac.01193-07 | Staphylococcus aureus | 2 |
| 18663023 | 10.1128/aac.01193-07 | Enterococcus faecalis | 2 |
| 18663023 | 10.1128/aac.01193-07 | Bacterial 70S ribosome | 2 |
| 18663023 | 10.1128/aac.01193-07 | Enterococcus faecium | 1 |
Data from ChEMBL 36 via Core Engine