Compound Detail
CHEMBL461534
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Basic Information
| ChEMBL ID | CHEMBL461534 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IBXDWOGXZNFARB-IBGZPJMESA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
417.5
MW (Da)
3.40
ALogP
4
HBA
2
HBD
70.7
PSA (Ų)
0.61
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
| Bacterial 70S ribosome CHEMBL2363135 | IC50 | 4.35 | 4.35 | 45000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 60.0 | nM | 7.22 | Inhibition of 50S ribosomal subunit purified from linezolid-,erythromycin-resist... | 18663023 |
| Bacterial 70S ribosome | IC50 | = | 45000.0 | nM | 4.35 | Displacement of [3H]chloramphenicol from 70S ribosomal complex in Staphylococcus... | 18663023 |
Literature References
Data from ChEMBL 36 via Core Engine