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Compound Detail

CHEMBL1241590

FLORFENICOL
🧪 Phase II
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🧪 Phase II
CS(=O)(=O)c1ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc1

Basic Information

ChEMBL ID CHEMBL1241590
Name FLORFENICOL
Phase Phase II
Structure Type MOL
InChI Key AYIRNRDRBQJXIF-NXEZZACHSA-N

Known Names

Florfenicol Florfenicol component of osurnia Florfenicol component of zeleris NSC-759287 Nuflor SCH 25298 SCH-25298
2
Targets
11
Activities
1
Assay Types
20
PK Parameters
20
Publications
7
Known Names

Molecular Properties

358.2
MW (Da)
1.38
ALogP
4
HBA
2
HBD
83.5
PSA (Ų)
0.75
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer
USAN Stem -fenicol
USAN Year 1986

Extended Properties

Molecular Formula C12H14Cl2FNO4S
MW 358.22
Aromatic Rings 1
Heavy Atoms 21
NP-Likeness -0.43

Activity Summary

IC50 11 meas. best 6.16

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 6.16 5.151 700.0 10
Bacterial 70S ribosome
CHEMBL2363135
IC50 4.7 4.7 20000.0 1

Pharmacokinetic Data

Parameter Value Units Species
AUC 21300.0 ng.hr.mL-1 Columba livia
AUC 12470.0 ng.hr.mL-1 Columba livia
AUC 22720.0 ng.hr.mL-1 Columba livia
AUC 13090.0 ng.hr.mL-1 Columba livia
CL 23.5 mL.min-1.kg-1 Columba livia
CL 22.0 mL.min-1.kg-1 Columba livia
CL 49.5 mL.min-1.kg-1 Columba livia
CL 8.71 mL.min-1.g-1 Homo sapiens
CL 69.18 uL.min-1.(10^6cells)-1 Rattus norvegicus
Cmax 14237.06 nM Columba livia
F 58.54 % Columba livia
F 60.0 % Columba livia
Ka 0.775 /hr Columba livia
T1/2 1.73 hr Columba livia
T1/2 2.69 hr Columba livia
T1/2 0.56 hr Columba livia
Tmax 0.69 hr Columba livia
Vd 2.02 L.kg-1 Columba livia
Vd 0.88 L.kg-1 Columba livia
Vd 0.56 L.kg-1 Columba livia

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18443112 10.1128/aac.00084-08 Salmonella typhimurium 41
18180355 10.1128/aac.00575-07 Columba livia 20
20696876 10.1128/aac.00139-10 Escherichia coli 16
18299405 10.1128/aac.01583-07 Staphylococcus aureus 12
18180355 10.1128/aac.00575-07 Salmonella typhimurium 7
19047652 10.1128/aac.01376-08 Staphylococcus aureus 5
20921317 10.1128/aac.01113-10 Staphylococcus aureus 4
- 10.6019/CHEMBL3301361 ADMET 3
20855745 10.1128/aac.00580-10 Escherichia coli 3
19015337 10.1128/aac.01015-08 NON-PROTEIN TARGET 3
18663023 10.1128/aac.01193-07 Unchecked 3
18180355 10.1128/aac.00575-07 ADMET 3
20065060 10.1128/aac.01208-09 Clostridium perfringens 3
19029319 10.1128/aac.01312-08 Edwardsiella ictaluri 2
19029319 10.1128/aac.01312-08 Escherichia coli 2
22483632 10.1016/j.ejmech.2012.03.008 Escherichia coli 2
18663023 10.1128/aac.01193-07 Enterococcus faecalis 2
18663023 10.1128/aac.01193-07 Staphylococcus aureus 2
19687245 10.1128/aac.00853-09 Streptomyces coelicolor 2
20585133 10.1128/aac.00169-10 Staphylococcus aureus 2

Data from ChEMBL 36 via Core Engine