Compound Detail
CHEMBL455461
RADEZOLID 🧪 Phase II
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🧪 Phase II
CC(=O)NC[C@H]1CN(c2ccc(-c3ccc(CNCc4cnn[nH]4)cc3)c(F)c2)C(=O)O1
Basic Information
| ChEMBL ID | CHEMBL455461 |
| Name | RADEZOLID |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | BTTNOGHPGJANSW-IBGZPJMESA-N |
1
Targets
2
Activities
1
Assay Types
3
PK Parameters
20
Publications
6
Known Names
1
Indications
1
Mechanisms
Molecular Properties
438.5
MW (Da)
2.36
ALogP
6
HBA
3
HBD
112.2
PSA (Ų)
0.50
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Bacterial 70S ribosome inhibitor | INHIBITOR | Bacterial 70S ribosome | ✓ | ✓ |
Indications
Pneumonia
Activity Summary
IC50 2 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.7 | 7.61 | 20.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.1 | hr | Homo sapiens |
| T1/2 | 0.1 | hr | Mus musculus |
| T1/2 | 0.1 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 20.0 | nM | 7.7 | Inhibition of 50S ribosomal subunit purified from Staphylococcus aureus ATCC 292... | 18663023 |
| Unchecked | IC50 | = | 30.0 | nM | 7.52 | Inhibition of 50S ribosomal subunit purified from linezolid-,erythromycin-resist... | 18663023 |
Literature References
Data from ChEMBL 36 via Core Engine