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Compound Detail

CHEMBL5077172

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Cc1cc(/N=N/c2ccccc2)ccc1OCCc1ccc(OC(C)(C)C(=O)O)cc1

Basic Information

ChEMBL ID CHEMBL5077172
Phase Preclinical
Structure Type MOL
InChI Key YMTMRPQOYKGHHI-CYYJNZCTSA-N
3
Targets
3
Activities
1
Assay Types
1
PK Parameters
5
Publications
0
Known Names

Molecular Properties

418.5
MW (Da)
6.27
ALogP
5
HBA
1
HBD
80.5
PSA (Ų)
0.42
QED
1
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H26N2O4
MW 418.49
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -0.54

Activity Summary

EC50 3 meas. best 8.15

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Peroxisome proliferator-activated receptor alpha
CHEMBL239
EC50 8.15 8.15 7.0 1
Peroxisome proliferator-activated receptor delta
CHEMBL3979
EC50 6.27 6.27 540.0 1
Peroxisome proliferator-activated receptor gamma
CHEMBL235
EC50 5.92 5.92 1200.0 1

Pharmacokinetic Data

Parameter Value Units Species
T1/2 1.717 hr Rattus norvegicus

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
34213899 10.1021/acs.jmedchem.1c00810 Peroxisome proliferator-activated receptor alpha 6
34213899 10.1021/acs.jmedchem.1c00810 Peroxisome proliferator-activated receptor delta 3
34213899 10.1021/acs.jmedchem.1c00810 Peroxisome proliferator-activated receptor gamma 2
34213899 10.1021/acs.jmedchem.1c00810 ADMET 1
34213899 10.1021/acs.jmedchem.1c00810 No relevant target 1

Data from ChEMBL 36 via Core Engine