Assay Detail
Binding
CHEMBL5033439
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Agonist activity at Gal4-fused human PPARalpha LBD transfected in HEK293T cells assessed as transcriptional activation incubated for 14 to 16 hrs by dual-Glo luciferase assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A Photohormone for Light-Dependent Control of PPARα in Live Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.65 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5077172 | — | — | 1 | 8.15 |
| CHEMBL5075710 | — | — | 1 | 8.05 |
| CHEMBL5079792 | — | — | 1 | 7.54 |
| CHEMBL5078989 | — | — | 1 | 7.44 |
| CHEMBL5090762 | — | — | 1 | 7.40 |
| CHEMBL5093897 | — | — | 1 | 7.40 |
| CHEMBL5091066 | — | — | 1 | 7.16 |
| CHEMBL5078096 | — | — | 1 | 7.15 |
| CHEMBL5090355 | — | — | 1 | 6.72 |
| CHEMBL5087538 | — | — | 1 | 6.62 |
| CHEMBL5093865 | — | — | 1 | 6.55 |
| CHEMBL5090334 | — | — | 1 | 6.54 |
| CHEMBL5085675 | — | — | 1 | 6.33 |
| CHEMBL5090373 | — | — | 1 | 6.19 |
| CHEMBL5090949 | — | — | 1 | 6.18 |
| CHEMBL4471853 | — | — | 1 | 6.10 |
| CHEMBL5087457 | — | — | 1 | 6.10 |
| CHEMBL5078286 | — | — | 1 | 5.96 |
| CHEMBL5075561 | — | — | 1 | 5.96 |
| CHEMBL2204696 | — | — | 1 | 5.96 |
| CHEMBL5079941 | — | — | 1 | 5.46 |
| CHEMBL2204695 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5077172 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5075710 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5079792 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5078989 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5090762 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5093897 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5091066 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5078096 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5090355 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5087538 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5093865 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5090334 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5085675 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5090373 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5090949 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4471853 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5087457 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5078286 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5075561 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2204696 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL5079941 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2204695 | — | EC50 | = | 3700.0 | nM | 5.43 |