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Compound Detail

CHEMBL5079941

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CC(C)(Oc1ccc(COc2ccc(/N=N\c3ccccc3)cc2)cc1)C(=O)O

Basic Information

ChEMBL ID CHEMBL5079941
Phase Preclinical
Structure Type MOL
InChI Key GAKQARXXOLKBGC-IZHYLOQSSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

390.4
MW (Da)
5.92
ALogP
5
HBA
1
HBD
80.5
PSA (Ų)
0.48
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H22N2O4
MW 390.44
Aromatic Rings 3
Heavy Atoms 29
NP-Likeness -0.51

Activity Summary

EC50 3 meas. best 5.46

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Peroxisome proliferator-activated receptor alpha
CHEMBL239
EC50 5.46 5.46 3500.0 1
Peroxisome proliferator-activated receptor delta
CHEMBL3979
EC50 5.39 5.39 4100.0 1
Peroxisome proliferator-activated receptor gamma
CHEMBL235
EC50 5.18 5.18 6600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
34213899 10.1021/acs.jmedchem.1c00810 Peroxisome proliferator-activated receptor delta 2
34213899 10.1021/acs.jmedchem.1c00810 Peroxisome proliferator-activated receptor gamma 2
34213899 10.1021/acs.jmedchem.1c00810 Peroxisome proliferator-activated receptor alpha 2

Data from ChEMBL 36 via Core Engine